In contrast, the morphology of necrosis is distinctly different and is characterized by swelling and degeneration of the entire cytoplasm.
Alterations in the activity of Bcl-2 family members may underlie the differential sensitivity of proximal tubular vs.
For example, both heat stress and hypoxia are settings where damage to the cytoskeleton occurs, where there is mitochondrial swelling, and where there is uncoupling of oxidative phosphorylation.
Oxidative stress in the kidney also enhances the vasoconstrictor effects of adenosine.
Although there is evidence of a positive growth effect of such inflows in the short run, that positive impact dissipates after 5 years and turns negative over longer horizons.
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Everest was not taller… or shorter.